Clue cells

Definition

Clue cells are vaginal epithelial cells that are covered with bacteria, giving them a stippled appearance under a microscope. They are a key diagnostic indicator of bacterial vaginosis.

5 Must Know Facts For Your Next Test

1. Clue cells are typically identified using a wet mount preparation of vaginal discharge.
2. The presence of clue cells indicates an overgrowth of anaerobic bacteria, such as Gardnerella vaginalis.
3. A high number of clue cells is one of the Amsel criteria used for diagnosing bacterial vaginosis.
4. Clue cells have indistinct borders due to the coating of bacteria obscuring their edges.
5. They can be differentiated from normal epithelial cells by their granular appearance and lack of clear cell margins.

Related terms

Bacterial Vaginosis:

A condition characterized by an imbalance in the vaginal microbiota, leading to symptoms like discharge and odor.

Gardnerella Vaginalis: A type of anaerobic bacteria commonly associated with bacterial vaginosis and found on clue cells.

Amsel Criteria:

A clinical set of criteria used to diagnose bacterial vaginosis, which includes the presence of clue cells.