Written by the Fiveable Content Team • Last updated August 2025
Verified for the 2026 exam
Verified for the 2026 exam•Written by the Fiveable Content Team • Last updated August 2025
Definition
Capsaicin is a compound found in hot peppers that activates the TRPV1 receptor, leading to the sensation of heat or physical abrasiveness. It stimulates nerve endings, resulting in the perception of pain and a release of endorphins.
TRPV1 receptor: This is a receptor found on sensory neurons that responds to capsaicin and other stimuli related to temperature and pain.
Sensation of heat: The perception of warmth or high temperature experienced when capsaicin binds to the TRPV1 receptor.
Physical abrasiveness: The feeling of irritation or roughness caused by capsaicin activating the TRPV1 receptor, even though no physical harm is occurring.