Transpeptidase

Definition

Transpeptidase is an enzyme that catalyzes the cross-linking of peptidoglycan chains to form the bacterial cell wall. It is a crucial target for certain antibacterial drugs.

5 Must Know Facts For Your Next Test

1. Transpeptidase enzymes are also known as penicillin-binding proteins (PBPs).
2. Beta-lactam antibiotics, such as penicillin, inhibit transpeptidase activity.
3. Inhibition of transpeptidase leads to weakened bacterial cell walls and cell lysis.
4. Mutations in transpeptidase genes can lead to antibiotic resistance in bacteria.
5. Transpeptidase activity is essential for bacterial growth and division.

Review Questions

Related terms

Peptidoglycan:

A polymer that forms a protective layer around bacterial cells, giving them structural strength.

Beta-Lactam Antibiotics:

A class of antibiotics that inhibit the synthesis of bacterial cell walls by targeting transpeptidases.

Penicillin-Binding Proteins (PBPs): A group of proteins, including transpeptidases, that are targeted by beta-lactam antibiotics.