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Coenzyme A (CoA)

Written by the Fiveable Content Team • Last updated August 2025
Written by the Fiveable Content Team • Last updated August 2025

Definition

Coenzyme A (CoA) is a molecule that plays a crucial role in the metabolism of carbohydrates, fats, and proteins. It acts as a carrier of acyl groups in various biochemical reactions.

5 Must Know Facts For Your Next Test

  1. Coenzyme A is essential for the formation of acetyl-CoA, which enters the citric acid cycle.
  2. It participates in the synthesis and oxidation of fatty acids.
  3. CoA is derived from pantothenic acid (vitamin B5).
  4. It plays a key role in the transfer of acetyl groups during metabolic processes.
  5. Its thioester bond with acyl groups makes it highly reactive and efficient in biochemical reactions.
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