🦠microbiology review

Spiramycin

Written by the Fiveable Content Team • Last updated August 2025
Written by the Fiveable Content Team • Last updated August 2025

Definition

Spiramycin is a macrolide antibiotic used to treat bacterial and parasitic infections. It is particularly effective against Toxoplasma gondii, often prescribed for toxoplasmosis in pregnant women.

5 Must Know Facts For Your Next Test

  1. Spiramycin inhibits protein synthesis by binding to the 50S ribosomal subunit of bacteria.
  2. It is commonly used to treat toxoplasmosis, especially in pregnant women due to its safety profile.
  3. Spiramycin has a broad spectrum of activity against Gram-positive bacteria and some Gram-negative bacteria.
  4. The drug is not available in the United States but can be obtained through the Centers for Disease Control and Prevention (CDC) for specific cases.
  5. It has a long half-life, allowing for less frequent dosing compared to other antibiotics.
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