Viral neuraminidase

Definition

Viral neuraminidase is an enzyme present on the surface of influenza viruses that facilitates the release of newly formed viral particles from infected cells. It cleaves sialic acid residues, aiding in viral spread within the host.

5 Must Know Facts For Your Next Test

1. Neuraminidase inhibitors are a class of antiviral drugs that target this enzyme to prevent virus proliferation.
2. Influenza types A and B both possess neuraminidase enzymes with different subtypes such as N1, N2, etc.
3. The activity of neuraminidase is crucial for the efficient transmission of influenza viruses between hosts.
4. Mutations in neuraminidase can lead to antiviral resistance, complicating treatment strategies.
5. Neuraminidase plays a role in determining the virulence and pathogenicity of influenza strains.

Related terms

Hemagglutinin:

A glycoprotein found on the surface of influenza viruses that allows binding to host cells.

Sialic Acid: A sugar molecule found on the surface of cells that is cleaved by neuraminidase.

Oseltamivir:

An antiviral medication used to treat and prevent influenza by inhibiting neuraminidase.