Transendothelial migration

Definition

Transendothelial migration is the process by which immune cells move from the bloodstream across the endothelial layer into tissues. This is a critical step in the immune response to infection and inflammation.

5 Must Know Facts For Your Next Test

1. Transendothelial migration involves multiple steps including rolling, adhesion, and diapedesis.
2. Endothelial cells express adhesion molecules like selectins and integrins that facilitate the capture and movement of immune cells.
3. Chemokines play a crucial role by signaling immune cells to migrate towards sites of infection or injury.
4. Neutrophils are one of the primary types of immune cells that undergo transendothelial migration during an acute inflammatory response.
5. Dysregulation in transendothelial migration can contribute to various diseases such as chronic inflammation, autoimmunity, and cancer.

Related terms

Phagocytosis:

The process by which certain cells engulf and digest pathogens and debris.

Chemokine: A type of cytokine that plays a key role in directing cell movement towards sites of inflammation or injury.

Endothelium: A thin layer of cells lining the blood vessels that regulate exchanges between the bloodstream and surrounding tissues.