Pertussis toxin (PT)

Definition

Pertussis toxin (PT) is a protein exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. It interferes with normal cellular signaling, leading to increased mucus production and immune system disruption.

5 Must Know Facts For Your Next Test

1. PT is a key virulence factor of Bordetella pertussis.
2. It functions by ADP-ribosylating G proteins, which disrupts cellular communication.
3. The toxin consists of five subunits: S1 through S5.
4. PT is responsible for many of the symptoms associated with whooping cough, including paroxysmal coughing and lymphocytosis.
5. Vaccines like DTaP include components that provide immunity against PT.

Related terms

Bordetella pertussis:

A Gram-negative bacterium that causes whooping cough.

DTaP vaccine: A combination vaccine that protects against diphtheria, tetanus, and pertussis.

Exotoxin: A toxin released by bacteria into the surrounding environment.