free diagnosticupgrade

🦠microbiology review

Nalidixic acid

Written by the Fiveable Content Team • Last updated August 2025
Written by the Fiveable Content Team • Last updated August 2025

Definition

Nalidixic acid is a synthetic antibacterial agent primarily used to treat urinary tract infections. It belongs to the quinolone class of antibiotics and inhibits bacterial DNA replication.

AP course connection

Topic 14.3: 14.3 Mechanisms of Antibacterial Drugs

Unit 14

Keep studying

Review this concept in 14.3 Mechanisms of Antibacterial DrugsMicrobiology course hub

nalidixic acid cheat sheet for homework

visual study aid

5 Must Know Facts For Your Next Test

  1. Nalidixic acid targets bacterial DNA gyrase, an enzyme crucial for DNA replication.
  2. It was the first quinolone antibiotic, discovered in the early 1960s.
  3. Nalidixic acid is effective mainly against Gram-negative bacteria such as E. coli.
  4. Resistance to nalidixic acid can develop through mutations in the genes encoding DNA gyrase or increased efflux pump activity.
  5. Common side effects include gastrointestinal discomfort and potential CNS effects like dizziness or seizures.
2,589 studying →