Exotoxin A

Definition

Exotoxin A is a potent toxin produced by Pseudomonas aeruginosa. It disrupts protein synthesis in host cells, leading to cell death.

5 Must Know Facts For Your Next Test

1. Exotoxin A is one of the main virulence factors of Pseudomonas aeruginosa.
2. It ADP-ribosylates elongation factor-2 (EF-2), inhibiting protein synthesis.
3. Exotoxin A is associated with severe skin infections like ecthyma gangrenosum.
4. The gene encoding Exotoxin A is typically regulated by iron levels in the environment.
5. Antibiotic resistance in Pseudomonas aeruginosa complicates treatment of infections involving Exotoxin A.

Related terms

Pseudomonas aeruginosa:

A gram-negative bacterium known for causing various human infections, including those of the skin and eyes.

Ecthyma gangrenosum: A necrotic skin infection often linked to Pseudomonas aeruginosa.

Elongation factor-2 (EF-2): A protein involved in the translation phase of protein synthesis that can be targeted by bacterial toxins like Exotoxin A.