Cytokine storm

Definition

A cytokine storm is an excessive and uncontrolled release of pro-inflammatory cytokines, often resulting from an overactive immune response. It can lead to severe inflammation and tissue damage, particularly in the respiratory system.

5 Must Know Facts For Your Next Test

1. Cytokine storms are associated with severe viral infections such as influenza and COVID-19.
2. They can result in acute respiratory distress syndrome (ARDS) due to extreme inflammation in the lungs.
3. Cytokine storms involve key cytokines like interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma).
4. Immunosuppressive treatments like corticosteroids are sometimes used to manage cytokine storms.
5. Early detection and intervention are crucial for reducing morbidity and mortality associated with cytokine storms.

Review Questions

Related terms

Interleukin-6 (IL-6): A pro-inflammatory cytokine often elevated during a cytokine storm.

Acute Respiratory Distress Syndrome (ARDS): A severe lung condition that can be triggered by a cytokine storm.

Tumor Necrosis Factor-alpha (TNF-alpha): A key inflammatory mediator involved in the development of a cytokine storm.