🦠microbiology review

Periplasmic space

Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025

Definition

The periplasmic space is the area between the inner cytoplasmic membrane and the outer membrane in Gram-negative bacteria. It contains a gel-like matrix rich in enzymes and other proteins.

5 Must Know Facts For Your Next Test

  1. The periplasmic space is unique to Gram-negative bacteria.
  2. It contains enzymes that are crucial for nutrient processing and defense against harmful substances.
  3. This space helps in the transport of molecules into and out of the cell.
  4. It plays a role in maintaining cell morphology and structural integrity.
  5. Antibiotic resistance mechanisms, such as beta-lactamase activity, often occur within this space.

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