🦠microbiology review

Penciclovir

Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025

Definition

Penciclovir is an antiviral medication used to treat herpes simplex virus infections, particularly cold sores. It works by inhibiting viral DNA replication, thus controlling the spread of the virus.

5 Must Know Facts For Your Next Test

  1. Penciclovir is commonly applied topically in cream form for treating cold sores.
  2. It specifically targets the herpes simplex virus types 1 and 2 (HSV-1 and HSV-2).
  3. Penciclovir has a longer intracellular half-life compared to acyclovir, making it effective for sustained antiviral activity.
  4. The medication is most effective when applied at the first sign of a cold sore outbreak.
  5. Common side effects include mild pain, irritation, or redness at the application site.

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