💀anatomy and physiology i review

Prepotential depolarization

Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025

Definition

Prepotential depolarization is the gradual increase in the electrical charge of cardiac pacemaker cells, which brings them to the threshold required to generate a heartbeat. This process ensures the heart beats at a regular pace without external stimuli.

Pep mascot