Median lethal dose (LD50)

Definition

Median lethal dose (LD50) is the amount of a substance required to kill 50% of a test population. It is commonly used in toxicology to assess the potency of pathogens, toxins, and chemicals.

5 Must Know Facts For Your Next Test

1. LD50 values are typically expressed in milligrams per kilogram of body weight (mg/kg).
2. A lower LD50 value indicates a more potent toxin or pathogen.
3. LD50 testing often uses animal models such as mice or rats for experimental consistency.
4. The concept of LD50 helps in comparing the relative toxicity of different substances.
5. Knowledge of LD50 is crucial for understanding the potential risks and required safety measures when handling pathogens.

Related terms

Toxicity: The degree to which a substance can harm living organisms.

Pathogenicity:

The ability of an organism to cause disease.

Dose-Response Relationship: The correlation between the amount of a substance and its overall effect on an organism.