Transendothelial migration is the process by which immune cells move from the bloodstream across the endothelial layer into tissues. This is a critical step in the immune response to infection and inflammation.
5 Must Know Facts For Your Next Test
Transendothelial migration involves multiple steps including rolling, adhesion, and diapedesis.
Endothelial cells express adhesion molecules like selectins and integrins that facilitate the capture and movement of immune cells.
Chemokines play a crucial role by signaling immune cells to migrate towards sites of infection or injury.
Neutrophils are one of the primary types of immune cells that undergo transendothelial migration during an acute inflammatory response.
Dysregulation in transendothelial migration can contribute to various diseases such as chronic inflammation, autoimmunity, and cancer.