Macrophages are large phagocytic cells derived from monocytes that play a crucial role in both innate and adaptive immunity. They engulf and digest pathogens, dead cells, and cellular debris.
5 Must Know Facts For Your Next Test
Macrophages can present antigens to T cells, linking innate and adaptive immune responses.
They release cytokines that modulate immune responses and inflammation.
Macrophages are found in virtually all tissues, acting as sentinels against infection.
They recognize pathogens through pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs).
Activated macrophages can differentiate into M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotypes depending on the signals they receive.