Antigen presenting cells (APCs)

Definition

Antigen Presenting Cells (APCs) are immune cells that capture antigens and present them on their surface to T-cells, initiating an immune response. Key APCs include dendritic cells, macrophages, and B-cells.

5 Must Know Facts For Your Next Test

1. APCs are crucial for the activation of T-cells.
2. Dendritic cells are considered the most potent APCs.
3. APCs express Major Histocompatibility Complex (MHC) molecules on their surface to present antigens.
4. Macrophages can act as APCs by engulfing pathogens and presenting their antigens.
5. B-cells can present antigens to helper T-cells, which is essential for antibody production.

Review Questions

• What is the primary function of Antigen Presenting Cells?
• Which type of cell is considered the most potent APC?
• How do APCs present antigens to T-cells?

Related terms

Major Histocompatibility Complex (MHC):

A set of cell surface proteins essential for acquired immune system recognition of foreign molecules.

Dendritic Cells:

Immune cells that are the most effective at antigen presentation and activating naive T-cells.

T-Cells: A type of lymphocyte that plays a central role in cell-mediated immunity.