Gray baby syndrome

Definition

Gray baby syndrome is a serious condition caused by the accumulation of the antibiotic chloramphenicol in neonates, leading to cyanosis and potentially fatal circulatory collapse. It occurs due to immature liver enzymes in infants that are unable to metabolize the drug effectively.

5 Must Know Facts For Your Next Test

1. Gray baby syndrome primarily affects premature and newborn infants.
2. The condition is linked to the usage of chloramphenicol, an antibiotic once widely used for bacterial infections.
3. Symptoms include vomiting, ashen gray skin color, hypotension, and hypothermia.
4. Immature liver function in neonates leads to inadequate drug metabolism and excretion of chloramphenicol.
5. Treatment involves discontinuing chloramphenicol and providing supportive care such as oxygen therapy or exchange transfusion.

Related terms

Chloramphenicol:

A broad-spectrum antibiotic that can cause serious side effects including gray baby syndrome.

Neonate: A newborn infant, especially one less than four weeks old.

Cyanosis: A bluish discoloration of the skin resulting from poor circulation or inadequate oxygenation of the blood.