Crisis phase

Definition

The crisis phase is the period during which the body's innate immune response reaches its peak in combating an infection, characterized by intense inflammation and fever. It marks a critical point where either recovery or severe disease progression can occur.

5 Must Know Facts For Your Next Test

1. The crisis phase involves heightened activity of white blood cells like macrophages and neutrophils.
2. During this phase, pro-inflammatory cytokines such as IL-1, IL-6, and TNF-alpha are released in large quantities.
3. Fever during the crisis phase helps to inhibit pathogen growth and enhances the efficiency of immune cells.
4. The resolution of the crisis phase often leads to the activation of adaptive immunity if the infection persists.
5. Uncontrolled or excessive responses during the crisis phase can result in tissue damage and sepsis.

Review Questions

• What role do pro-inflammatory cytokines play during the crisis phase?
• Why is fever considered beneficial during the crisis phase?
• What potential risks are associated with an uncontrolled response in the crisis phase?

Related terms

Inflammation: A biological response to harmful stimuli marked by redness, swelling, heat, and pain.

Fever: An elevated body temperature that enhances immune system efficiency against pathogens.

Cytokines: Signaling proteins that mediate and regulate immunity, inflammation, and hematopoiesis.