Aggregation

Definition

Aggregation in immunology refers to the clumping together of particles, such as cells or pathogens, often facilitated by antibodies. This process is crucial for enhancing the immune system's ability to target and eliminate foreign invaders.

5 Must Know Facts For Your Next Test

1. Aggregation enhances the efficiency of phagocytosis by immune cells.
2. Antibodies play a significant role in promoting aggregation by binding to antigens.
3. Aggregation can help neutralize toxins produced by pathogens.
4. Immune complexes formed during aggregation are often cleared by macrophages in the liver and spleen.
5. Excessive or inappropriate aggregation can lead to immune complex diseases.

Review Questions

• How does aggregation contribute to the efficiency of phagocytosis?
• What role do antibodies play in the process of aggregation?
• Why is it important for immune complexes formed during aggregation to be cleared?

Related terms

Phagocytosis:

The process by which cells, like macrophages, engulf and digest foreign particles.

Antigen-Antibody Complex:

A structure formed when an antibody binds to its specific antigen.

Immune Complex Diseases: Conditions that arise from the deposition of immune complexes in tissues, leading to inflammation and tissue damage.