Written by the Fiveable Content Team • Last updated September 2025
Written by the Fiveable Content Team • Last updated September 2025
Definition
Systemic circulation is the part of the circulatory system that carries oxygenated blood from the heart to the body and returns deoxygenated blood back to the heart. It is essential for delivering nutrients and removing waste products from tissues.
5 Must Know Facts For Your Next Test
Systemic circulation starts in the left ventricle and ends in the right atrium.
The aorta is the main artery that distributes oxygen-rich blood throughout systemic circulation.
Capillaries are where gas exchange occurs between blood and tissues.
The superior and inferior vena cavae return deoxygenated blood to the right atrium.
Systemic circulation works in conjunction with pulmonary circulation to maintain overall blood flow and oxygenation.
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Related terms
Pulmonary Circulation: The part of the circulatory system that carries deoxygenated blood from the heart to the lungs and brings oxygenated blood back to the heart.
Aorta: The largest artery in the body, responsible for distributing oxygen-rich blood from the left ventricle to all parts of the body.