Pathogen-associated molecular patterns (PAMPs)

Definition

Pathogen-associated molecular patterns (PAMPs) are conserved molecular structures found on the surface of many pathogens. They are recognized by the innate immune system as foreign, triggering an immune response.

5 Must Know Facts For Your Next Test

1. PAMPs are recognized by pattern recognition receptors (PRRs) on immune cells.
2. Common examples of PAMPs include lipopolysaccharides (LPS), flagellin, and peptidoglycan.
3. The detection of PAMPs is a crucial first step in activating the innate immune response.
4. Toll-like receptors (TLRs) are a major class of PRRs that detect PAMPs.
5. PAMPs can trigger inflammation, phagocytosis, and other defense mechanisms.

Review Questions

• What role do PAMPs play in the innate immune response?
• Name three common examples of PAMPs.
• Which type of receptor is primarily responsible for detecting PAMPs?

Related terms

Pattern Recognition Receptors (PRRs): Proteins on or in cells that recognize and bind to PAMPs.

Toll-Like Receptors (TLRs): A class of PRRs involved in recognizing pathogens and activating immune responses.

Innate Immune Response: The initial, non-specific defense mechanism against pathogens.