Confusing U_E (energy) with V (potential)
U_E is the energy of a charge configuration in joules; V is energy per unit charge in volts. The relation is U_E = qV only when V is the potential at the location of charge q due to all other charges. Mixing up the two leads to incorrect setup of energy-conservation equations.
Getting the sign of delta U_E wrong
delta U_E = q delta V requires both the sign of q and the sign of delta V = V_f - V_i. A negative charge moving to higher potential has a negative delta U_E (it gains kinetic energy), which is the opposite of what many students expect.
Treating V like a vector when superposing
Electric potential is a scalar. When finding V due to multiple charges, add the individual kqi/ri values algebraically, including their signs. Do not add them as vectors the way you would for electric field components.
Forgetting to count all unique pairs in multi-charge systems
For three charges, there are three unique pairs (1-2, 1-3, 2-3). Students often miss one pair or double-count. Systematically list every pair before summing.
Misapplying E_x = -dV/dx direction
The electric field points in the direction of decreasing potential, not increasing potential. If V increases in the +x direction, E_x is negative (field points in -x). Sketch V vs. x and take the negative slope to avoid sign errors.