Clonal deletion

Definition

Clonal deletion is a process within the immune system where B-lymphocytes (B-cells) that react against the body's own tissues are identified and eliminated during their development in the bone marrow. This mechanism ensures self-tolerance, preventing autoimmune diseases.

Related terms

Autoimmunity: The failure of an organism to recognize its own constituent parts as self, leading to an immune response against its own cells and tissues.

Self: tolerance - The ability of the immune system to recognize and not mount an attack against the body’s own tissues and cells.

B: lymphocytes (B-cells) - A type of white blood cell that is part of the immune system and produces antibodies in response to antigens