Induced fit

Definition

Induced fit is a model describing how enzymes change shape to accommodate the substrate, enhancing the enzyme's ability to catalyze the reaction. This dynamic adjustment increases specificity and efficiency in biochemical reactions.

5 Must Know Facts For Your Next Test

1. The induced fit model was proposed by Daniel Koshland in 1958.
2. It contrasts with the older 'lock and key' model which suggested that enzyme active sites are rigid.
3. Induced fit involves conformational changes in both the enzyme and the substrate.
4. This model explains why enzymes can be highly specific to their substrates.
5. Induced fit enhances catalytic activity by optimizing the alignment of reactive groups.

Review Questions

Related terms

Active Site:

The region on an enzyme where substrate molecules bind and undergo a chemical reaction.

Catalysis:

The acceleration of a chemical reaction by a catalyst, such as an enzyme.

Substrate:

The substance on which an enzyme acts during a biochemical reaction.