Diapedesis

Definition

Diapedesis is the process by which white blood cells move through the walls of blood vessels to reach affected tissues. This is a critical step in the immune response to infection or injury.

5 Must Know Facts For Your Next Test

1. Diapedesis involves the movement of leukocytes, particularly neutrophils and monocytes, from the bloodstream into tissues.
2. The process is initiated by signaling molecules like cytokines and chemokines released at sites of infection or injury.
3. Endothelial cells lining blood vessels become more permeable during diapedesis, allowing white blood cells to pass through.
4. Diapedesis is essential for phagocytosis, where leukocytes engulf and destroy pathogens.
5. The process helps localize the immune response, ensuring that white blood cells reach and combat pathogens effectively.

Review Questions

Related terms

Chemotaxis:

The movement of organisms or cells in response to chemical stimuli.

Phagocytosis:

The ingestion of bacteria or other material by phagocytes.

Cytokines:

Small proteins released by cells that have a specific effect on interactions and communications between cells.