CD34

Definition

CD34 is a cell surface glycoprotein that serves as a marker for hematopoietic stem cells and endothelial progenitor cells. This protein plays a crucial role in cell adhesion and migration, making it essential for the development and repair of tissues, particularly in the context of vascular biology and regenerative medicine.

5 Must Know Facts For Your Next Test

1. CD34 is widely used as a biomarker to identify hematopoietic stem cells in bone marrow and peripheral blood, which is important for both research and clinical applications.
2. In regenerative medicine, CD34+ cells have been shown to enhance tissue repair by promoting angiogenesis, the formation of new blood vessels from existing ones.
3. The presence of CD34 on endothelial progenitor cells indicates their potential to contribute to neovascularization and improve blood supply to injured tissues.
4. CD34+ cells can be isolated from various sources such as bone marrow, umbilical cord blood, and peripheral blood, making them versatile for therapeutic uses.
5. Research has indicated that CD34+ cell therapy may improve outcomes in patients with cardiovascular diseases by promoting heart repair and improving cardiac function.

Review Questions

• How does CD34 function as a marker in identifying stem cells, and why is this important in regenerative medicine?
  • CD34 acts as a key marker for identifying hematopoietic stem cells and endothelial progenitor cells. Its presence allows researchers and clinicians to isolate these specific cell types effectively, which is crucial for applications in regenerative medicine. By focusing on CD34+ cells, therapies can target those with the greatest potential for tissue repair and regeneration, particularly in treating conditions like cardiovascular disease.
• Evaluate the role of CD34+ endothelial progenitor cells in the process of angiogenesis during heart repair.
  • CD34+ endothelial progenitor cells play a significant role in angiogenesis, which is vital for heart repair following injury. These cells are involved in forming new blood vessels that restore blood flow to damaged areas of the heart. Their ability to migrate to sites of injury and differentiate into endothelial cells facilitates the regeneration of vascular networks, ultimately improving cardiac function and recovery post-infarction.
• Synthesize information on how CD34+ cell therapy could influence future treatments for cardiovascular diseases based on current research findings.
  • Current research suggests that CD34+ cell therapy holds promising potential for revolutionizing treatments for cardiovascular diseases. By harnessing the regenerative properties of CD34+ cells, this therapy aims to enhance heart repair mechanisms through improved angiogenesis and tissue regeneration. As studies continue to demonstrate positive outcomes in enhancing cardiac function and reducing scar tissue formation post-myocardial infarction, the incorporation of CD34+ cell therapy into clinical practice could provide new avenues for managing heart disease effectively.

Related terms

Hematopoietic Stem Cells:

These are the stem cells responsible for the production of blood cells, which can differentiate into various types of blood cells including red blood cells, white blood cells, and platelets.

Endothelial Progenitor Cells: These are a type of stem cell that contributes to the formation and repair of blood vessels by differentiating into endothelial cells, which line the interior surface of blood vessels.

Stem Cell Therapy: A medical treatment that utilizes stem cells to regenerate damaged tissues or organs, potentially providing new options for treating various diseases and injuries.