Radiobiology
Base excision repair (BER) is a crucial DNA repair mechanism that removes and replaces damaged or non-canonical bases in DNA. This process is vital for maintaining genomic integrity, as it specifically targets small-scale lesions like oxidized, alkylated, or deaminated bases, which can lead to mutations if left unrepaired. BER works through a series of coordinated steps involving DNA glycosylases, which recognize and excise the faulty base, followed by the recruitment of other enzymes to fill in the gap and restore the correct DNA sequence.
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