Position-momentum uncertainty is a fundamental principle in quantum mechanics that states there is a limit to how precisely we can simultaneously know the position and momentum of a particle. This principle is encapsulated in the Heisenberg Uncertainty Principle, which asserts that the more accurately we know a particle's position, the less accurately we can know its momentum, and vice versa. This intrinsic limitation challenges classical notions of measurement and emphasizes the probabilistic nature of quantum systems.