The Heisenberg Uncertainty Principle states that it is impossible to simultaneously know both the exact position and exact momentum of a particle. This principle highlights the fundamental limits of measurement in quantum mechanics, emphasizing that the act of measuring one property inherently disturbs the other. This concept is crucial for understanding wave-particle duality, where particles exhibit both wave-like and particle-like properties, and it relates closely to the de Broglie wavelength, which describes the wave characteristics associated with particles.