Zyflo

Definition

Zyflo is a leukotriene synthesis inhibitor used to manage asthma by reducing inflammation and bronchoconstriction. The active ingredient, zileuton, inhibits the enzyme 5-lipoxygenase.

5 Must Know Facts For Your Next Test

1. Zyflo (zileuton) works by inhibiting the enzyme 5-lipoxygenase, which blocks leukotriene production.
2. It is primarily used in the long-term management of chronic asthma but not for acute asthma attacks.
3. Zyflo can cause liver enzyme elevations; hence, regular liver function tests are recommended.
4. Common side effects include headache, dyspepsia, and nausea.
5. The drug is administered orally and usually taken four times daily.

Review Questions

• What enzyme does Zyflo inhibit to prevent leukotriene synthesis?
• Why is Zyflo not suitable for treating acute asthma attacks?
• What are some important monitoring parameters for patients taking Zyflo?

Related terms

Leukotriene Modifiers: A class of drugs that includes agents like montelukast and zafirlukast which block leukotriene receptors or synthesis.

Xanthines: Bronchodilators such as theophylline that relax smooth muscles in the airways.

Mast Cell Stabilizers: Drugs like cromolyn sodium that prevent the release of histamine and other inflammatory mediators from mast cells.