VP-16

Definition

VP-16, also known as Etoposide, is a chemotherapeutic agent used primarily to treat various types of cancer including lung cancer and testicular cancer. It works by inhibiting the enzyme topoisomerase II, leading to DNA breakage and cell death.

5 Must Know Facts For Your Next Test

1. VP-16 is commonly administered intravenously or orally.
2. It is often used in combination with other chemotherapy drugs for enhanced efficacy.
3. Side effects may include low blood counts, nausea, hair loss, and increased risk of infection.
4. VP-16 can cause secondary malignancies such as acute myeloid leukemia (AML) due to its DNA-damaging effects.
5. The drug's effectiveness can be influenced by the patient's liver and kidney function.

Review Questions

• What is the primary mechanism of action of VP-16?
• Name two types of cancer commonly treated with VP-16.
• List three possible side effects of VP-16.

Related terms

Topoisomerase Inhibitors: A class of drugs that interfere with the action of topoisomerases, enzymes involved in DNA replication.

Cisplatin: A platinum-based chemotherapy drug often used in combination with VP-16.

Myelosuppression: A common side effect of many chemotherapeutic agents, characterized by decreased bone marrow activity resulting in reduced blood cell production.