Vepesid

Definition

Vepesid (etoposide) is a chemotherapeutic agent used primarily to treat various types of cancer, including lung cancer and testicular cancer. It works by inhibiting the enzyme topoisomerase II, which is essential for DNA replication and cell division.

5 Must Know Facts For Your Next Test

1. Vepesid is often administered intravenously or orally depending on the specific cancer being treated.
2. Etoposide can cause side effects such as nausea, vomiting, hair loss, and an increased risk of infection due to bone marrow suppression.
3. It is classified as a podophyllotoxin derivative and works by inducing DNA strand breaks.
4. Vepesid is sometimes used in combination with other chemotherapeutic agents for enhanced efficacy.
5. Dosage adjustments may be necessary in patients with renal or hepatic impairment.

Review Questions

• What type of enzyme does Vepesid inhibit to prevent cancer cell proliferation?
• List two common side effects associated with Vepesid treatment.
• Why might Vepesid dosage need adjustment in certain patients?

Related terms

Topoisomerase Inhibitors: A class of drugs that interfere with the action of topoisomerase enzymes, crucial for DNA replication.

Podophyllotoxin Derivatives: Chemical compounds derived from podophyllotoxin, used as anti-cancer agents.

Bone Marrow Suppression: A decrease in the production of blood cells, often a side effect of chemotherapy.