Valproic acid

Definition

Valproic acid is a medication primarily used to treat epilepsy and bipolar disorder. It also has applications in preventing migraine headaches.

5 Must Know Facts For Your Next Test

1. Valproic acid works by increasing the availability of gamma-aminobutyric acid (GABA) in the brain, which helps to reduce neuronal excitability.
2. Common side effects include gastrointestinal issues, weight gain, and tremors.
3. It is contraindicated in pregnancy due to the high risk of birth defects and developmental disorders.
4. Therapeutic drug monitoring is often required to ensure effective and safe plasma levels.
5. Valproic acid can interact with other medications such as aspirin and warfarin, potentially altering their effects.

Review Questions

• What is the primary mechanism of action of valproic acid?
• List three common side effects associated with valproic acid.
• Why is valproic acid contraindicated in pregnancy?

Related terms

Carbamazepine:

An anticonvulsant drug used primarily for epilepsy and neuropathic pain.

Lithium Carbonate: A mood stabilizer commonly used in the treatment of bipolar disorder.

Topiramate:

An anticonvulsant also used for migraine prevention and weight loss.