Ustekinumab

Definition

Ustekinumab is a monoclonal antibody used to treat moderate to severe plaque psoriasis, psoriatic arthritis, and Crohn's disease. It works by targeting interleukin-12 (IL-12) and interleukin-23 (IL-23), which are involved in inflammatory processes.

5 Must Know Facts For Your Next Test

1. Ustekinumab is administered via subcutaneous injection.
2. It is often used when other systemic therapies or phototherapy are inadequate or not tolerated.
3. Common side effects include upper respiratory infections, headache, and fatigue.
4. It can take several weeks to months to see the full therapeutic effects of Ustekinumab.
5. Patients receiving Ustekinumab should be monitored for signs of infection due to its immunosuppressive action.

Review Questions

• What are the primary conditions treated with Ustekinumab?
• How does Ustekinumab work on a molecular level?
• What are common side effects associated with Ustekinumab?

Related terms

Interleukin-12 (IL-12): A cytokine that plays a key role in the differentiation of naive T cells into Th1 cells.

Psoriatic Arthritis: An inflammatory arthritis associated with psoriasis, characterized by joint pain and swelling.

Monoclonal Antibody: Antibodies that are made by identical immune cells, all clones of a unique parent cell, designed to target specific antigens.