Trexall
from class: Pharmacology for Nurses Definition Trexall is a brand name for methotrexate, a medication used to treat certain cancers and autoimmune diseases. It works by inhibiting the growth of rapidly dividing cells and suppressing the immune system.
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Predict what's on your test 5 Must Know Facts For Your Next Test Trexall is commonly used in the treatment of rheumatoid arthritis and psoriasis. As a chemotherapeutic agent, Trexall is effective against leukemia, breast cancer, lung cancer, and osteosarcoma. Methotrexate inhibits dihydrofolate reductase, an enzyme involved in DNA synthesis. It can cause significant side effects such as hepatotoxicity, myelosuppression, and mucositis. Patients on Trexall often require folic acid supplementation to mitigate some side effects. Review Questions What are the primary medical conditions treated with Trexall? How does methotrexate work at the cellular level? What are some common side effects associated with Trexall?
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