Thioguanine
from class: Pharmacology for Nurses Definition Thioguanine is an antimetabolite chemotherapeutic drug used primarily to treat certain types of leukemia. It interferes with DNA synthesis, thereby inhibiting the proliferation of cancer cells.
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Predict what's on your test 5 Must Know Facts For Your Next Test Thioguanine is effective in treating acute myeloid leukemia (AML) and other hematologic malignancies. It is a purine analog that gets incorporated into DNA and RNA, causing cytotoxicity. Common side effects include myelosuppression, liver toxicity, and gastrointestinal disturbances. Thioguanine requires careful dose adjustment in patients with TPMT (thiopurine methyltransferase) deficiency to avoid severe toxicity. Regular blood tests are essential for monitoring thioguanine's therapeutic levels and adverse effects. Review Questions What type of cancer is thioguanine primarily used to treat? How does thioguanine exert its cytotoxic effects on cancer cells? Why is it important to monitor patients' TPMT enzyme levels when administering thioguanine?
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