Teratogenic

Definition

Teratogenic refers to substances or agents that can cause malformations or defects in a developing embryo or fetus. These agents can lead to congenital abnormalities when exposure occurs during pregnancy.

5 Must Know Facts For Your Next Test

1. Teratogens are most harmful during the first trimester of pregnancy, when organogenesis occurs.
2. Common teratogenic drugs include thalidomide, isotretinoin (Accutane), and certain antiepileptic medications.
3. The degree of teratogenicity depends on the dose and duration of exposure, as well as the specific stage of fetal development.
4. Healthcare providers must carefully consider the risk-benefit ratio when prescribing medications to pregnant women.
5. Teratogenic effects can range from minor physical anomalies to severe developmental disorders and stillbirth.

Review Questions

• What is the critical period during which teratogens are most harmful to a developing fetus?
• Name three drugs known for their teratogenic effects.
• How does the timing and dosage of exposure influence teratogenicity?

Related terms

Congenital Abnormalities: Defects or malformations present at birth, potentially caused by genetic factors or environmental influences like teratogens.

Organogenesis: The process by which organs form during the early stages of embryonic development, typically occurring in the first trimester.

Risk-Benefit Ratio: A consideration in pharmacology that weighs the potential benefits of a medication against its possible risks, crucial in prescribing drugs during pregnancy.