Stratum corneum

Definition

The stratum corneum is the outermost layer of the epidermis, composed mainly of dead keratinized cells. It acts as a primary barrier to protect underlying tissues from infection, dehydration, and chemicals.

5 Must Know Facts For Your Next Test

1. The stratum corneum consists of 15-20 layers of flattened, non-nucleated cells.
2. It plays a crucial role in the skin's barrier function and permeability.
3. Lipid content in the stratum corneum helps to maintain hydration by preventing water loss.
4. Certain dermatologic drugs are designed to penetrate the stratum corneum for therapeutic effects.
5. Desquamation is the process where cells in the stratum corneum are shed and replaced.

Review Questions

• What is the primary function of the stratum corneum?
• How does the lipid content in the stratum corneum contribute to skin hydration?
• Why is understanding the structure of the stratum corneum important for pharmacology?

Related terms

Epidermis: The outermost layer of skin that includes several sub-layers, including the stratum corneum.

Keratinocytes: Cells that produce keratin and make up most of the epidermis.

Desquamation: The process by which dead skin cells are shed from the surface of the skin.