Somavert

Definition

Somavert is a brand name for pegvisomant, a growth hormone receptor antagonist used to treat acromegaly by reducing the effects of excess growth hormone. It works by blocking growth hormone receptors, thereby decreasing the production of insulin-like growth factor-1 (IGF-1).

5 Must Know Facts For Your Next Test

1. Somavert is specifically used to treat acromegaly, which is caused by excessive secretion of growth hormone.
2. The drug is administered via subcutaneous injection, typically once daily.
3. Monitoring liver function tests is crucial when a patient is on Somavert due to potential hepatotoxicity.
4. Pegvisomant, the active ingredient in Somavert, directly antagonizes growth hormone receptors rather than inhibiting its secretion.
5. Common side effects include injection site reactions, flu-like symptoms, and increased liver enzymes.

Review Questions

• What condition is Somavert primarily used to treat?
• How is Somavert administered to patients?
• Why is it important to monitor liver function in patients taking Somavert?

Related terms

Acromegaly: A hormonal disorder that results from an excess of growth hormone (GH), often caused by a pituitary adenoma.

Growth Hormone (GH): A peptide hormone that stimulates growth, cell reproduction, and regeneration in humans and other animals.

Insulin-like Growth Factor-1 (IGF-1): A protein involved in the effects of growth hormone; elevated levels are associated with acromegaly.