Somatostatin analogs
from class: Pharmacology for Nurses Definition Somatostatin analogs are synthetic versions of the natural hormone somatostatin, used to inhibit the release of growth hormone and other hormones. They are commonly prescribed for conditions like acromegaly, neuroendocrine tumors, and severe diarrhea.
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Predict what's on your test 5 Must Know Facts For Your Next Test Somatostatin analogs work by binding to somatostatin receptors, which are G-protein coupled receptors found in various tissues. Common somatostatin analogs include octreotide, lanreotide, and pasireotide. They are primarily administered via subcutaneous or intramuscular injection due to poor oral bioavailability. In addition to inhibiting growth hormone, they also reduce insulin and glucagon secretion from the pancreas. Patients on somatostatin analog therapy require regular monitoring of blood sugar levels and thyroid function. Review Questions What are the main therapeutic uses of somatostatin analogs? Name two common side effects associated with somatostatin analog therapy. Explain how somatostatin analogs affect insulin and glucagon secretion.
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