Lewy Bodies: Lewy bodies are abnormal protein deposits that are primarily composed of aggregated SNCA and are a hallmark pathological feature of Parkinson's disease and other synucleinopathies.
Synucleinopathies: Synucleinopathies are a group of neurodegenerative disorders characterized by the abnormal accumulation and aggregation of the SNCA protein, including Parkinson's disease, Lewy body dementia, and multiple system atrophy.
Protein Misfolding: The SNCA protein is prone to misfolding and aggregation, leading to the formation of Lewy bodies and the subsequent neurodegeneration observed in Parkinson's disease and other synucleinopathies.