Sildenafil
from class:
Pharmacology for Nurses
Definition
Sildenafil is a medication commonly used to treat erectile dysfunction and pulmonary arterial hypertension. It works by inhibiting phosphodiesterase type 5 (PDE5), thereby enhancing the effects of nitric oxide and increasing blood flow.
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5 Must Know Facts For Your Next Test
- Sildenafil is marketed under the brand name Viagra for erectile dysfunction.
- It should be taken about 30 minutes to 4 hours before sexual activity, but not more than once daily.
- Common side effects include headaches, flushing, indigestion, nasal congestion, and impaired vision.
- Sildenafil should not be used in combination with nitrates due to the risk of severe hypotension.
- The drug was originally developed for hypertension and angina pectoris before its use for erectile dysfunction was discovered.
Review Questions
- What is the primary mechanism of action for sildenafil?
- List two common side effects associated with sildenafil use.
- Why should sildenafil not be taken with nitrate medications?
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