Sacubitril/valsartan

Definition

Sacubitril/valsartan is a combination medication used to treat heart failure. It combines an ARB (valsartan) and a neprilysin inhibitor (sacubitril) to improve cardiovascular outcomes.

5 Must Know Facts For Your Next Test

1. Sacubitril/valsartan reduces the risk of cardiovascular death and hospitalization in patients with heart failure.
2. Valsartan blocks the effects of angiotensin II, leading to vasodilation and reduced blood pressure.
3. Sacubitril inhibits neprilysin, which increases levels of natriuretic peptides that help reduce blood volume and pressure.
4. Common side effects include hypotension, hyperkalemia, and renal impairment.
5. Patients must discontinue ACE inhibitors at least 36 hours before starting sacubitril/valsartan to avoid angioedema.

Review Questions

• What are the primary components of sacubitril/valsartan, and what are their respective mechanisms of action?
• Why must ACE inhibitors be discontinued before initiating sacubitril/valsartan therapy?
• List common side effects associated with sacubitril/valsartan.

Related terms

Angiotensin II Receptor Blockers (ARBs): A class of drugs that block the effects of angiotensin II, leading to vasodilation.

Neprilysin Inhibitors: Medications that inhibit the enzyme neprilysin, increasing levels of natriuretic peptides.

ACE Inhibitors:

Drugs that inhibit the angiotensin-converting enzyme (ACE), reducing blood pressure and treating heart failure.