Rolapitant
from class: Pharmacology for Nurses Definition Rolapitant is a neurokinin-1 (NK1) receptor antagonist used to prevent delayed nausea and vomiting associated with chemotherapy. It works by blocking the action of substance P/neurokinin 1 on its receptors in the brain.
congrats on reading the definition of Rolapitant . now let's actually learn it.
Predict what's on your test 5 Must Know Facts For Your Next Test Rolapitant is specifically used to prevent delayed chemotherapy-induced nausea and vomiting (CINV). It is often administered in combination with other antiemetic drugs, such as serotonin (5-HT3) antagonists and corticosteroids. The drug has a long half-life of approximately 180 hours, allowing for sustained antiemetic effects. Rolapitant does not inhibit or induce CYP3A4 enzymes, reducing the risk of drug interactions common with other antiemetics. It is generally well-tolerated but can cause side effects like neutropenia, dizziness, and hiccups. Review Questions What type of receptor antagonist is Rolapitant? For what specific condition is Rolapitant primarily prescribed? Why might Rolapitant be preferred over other antiemetics in terms of drug interactions?
"Rolapitant" also found in:
© 2024 Fiveable Inc. All rights reserved. AP® and SAT® are trademarks registered by the College Board, which is not affiliated with, and does not endorse this website.