Rho kinase inhibitors are a class of medications that lower intraocular pressure by increasing the outflow of aqueous humor through the trabecular meshwork. They are primarily used in the treatment of glaucoma to prevent optic nerve damage.
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Rho kinase inhibitors reduce intraocular pressure by enhancing trabecular outflow.
They work by inhibiting the Rho kinase enzyme, which plays a role in cell contraction and cytoskeleton organization.
Common side effects include hyperemia (eye redness), corneal deposits, and subconjunctival hemorrhages.
Netarsudil is an example of a rho kinase inhibitor used in clinical practice.
These drugs can be used as monotherapy or in combination with other antiglaucoma agents.
Review Questions
What is the primary mechanism of action for rho kinase inhibitors in lowering intraocular pressure?
Name one common side effect associated with rho kinase inhibitors.
Can rho kinase inhibitors be used in combination with other antiglaucoma medications?
Related terms
Beta Blockers: A class of drugs that lower intraocular pressure by decreasing aqueous humor production.
Prostaglandin Analogs: Medications that reduce intraocular pressure by increasing uveoscleral outflow.
Carbonic Anhydrase Inhibitors: Drugs that decrease intraocular pressure by reducing aqueous humor production via inhibition of carbonic anhydrase enzymes.