Questran

Definition

Questran, also known as cholestyramine, is a bile acid sequestrant used to lower cholesterol levels in the blood. It works by binding bile acids in the intestine, preventing their reabsorption.

5 Must Know Facts For Your Next Test

1. Questran binds to bile acids in the gastrointestinal tract and forms an insoluble complex that is excreted in feces.
2. It is primarily used to treat hyperlipidemia and can also relieve pruritus associated with partial biliary obstruction.
3. Common side effects include constipation, bloating, and gas due to its action in the gut.
4. The drug may interfere with the absorption of other medications and vitamins such as fat-soluble vitamins (A, D, E, K).
5. Patients are often advised to take Questran before meals and mix it with water or juice for better administration.

Review Questions

• What mechanism does Questran use to lower cholesterol levels?
• Which side effects are commonly associated with Questran?
• How should patients be advised to take Questran for optimal effect?

Related terms

Bile Acid Sequestrants: A class of drugs that bind bile acids in the intestine to lower cholesterol levels.

Fibrates: Drugs that primarily reduce triglycerides and can increase HDL cholesterol.

Niacin: Also known as vitamin B3, it is used at pharmacologic doses to lower LDL cholesterol and triglycerides while raising HDL cholesterol.