Pyridostigmine bromide

Definition

Pyridostigmine bromide is a cholinesterase inhibitor that increases acetylcholine availability at neuromuscular junctions, used to treat myasthenia gravis. It improves muscle strength by preventing the breakdown of acetylcholine.

5 Must Know Facts For Your Next Test

1. Pyridostigmine bromide is commonly used to manage symptoms of myasthenia gravis.
2. It works by inhibiting the enzyme acetylcholinesterase, thereby increasing acetylcholine levels.
3. Typical side effects include gastrointestinal discomfort, increased salivation, and muscle cramps.
4. The drug has a relatively short half-life, requiring multiple doses throughout the day for effective symptom control.
5. Pyridostigmine bromide can also be used as a prophylactic treatment against nerve agent poisoning.

Review Questions

• What is the primary mechanism of action for pyridostigmine bromide?
• List three common side effects associated with pyridostigmine bromide.
• Why might pyridostigmine bromide require multiple doses per day?

Related terms

Acetylcholine: A neurotransmitter involved in muscle activation and other functions.

Myasthenia Gravis: An autoimmune disorder characterized by weakness and rapid fatigue of voluntary muscles.

Cholinesterase Inhibitor: A type of drug that prevents the breakdown of acetylcholine, thus enhancing its action.