Pyrazinamide

Definition

Pyrazinamide is an antitubercular medication used primarily in combination with other drugs to treat active tuberculosis. It works by disrupting the Mycobacterium tuberculosis cell membrane metabolism and transport functions.

5 Must Know Facts For Your Next Test

1. Pyrazinamide is most effective during the initial intensive phase of tuberculosis treatment.
2. Common side effects include hepatotoxicity, hyperuricemia, and gastrointestinal disturbances.
3. The drug is usually administered orally and has good penetration into tissues and fluids, including cerebrospinal fluid.
4. Pyrazinamide requires acidic conditions for its optimal activity against Mycobacterium tuberculosis.
5. It is contraindicated in patients with severe hepatic damage or acute gout.

Review Questions

• What is the primary use of Pyrazinamide in treating tuberculosis?
• List three common side effects associated with Pyrazinamide.
• Why is Pyrazinamide particularly effective in the initial phase of tuberculosis treatment?

Related terms

Isoniazid: An antitubercular drug that inhibits mycolic acid synthesis, essential for bacterial cell wall formation.

Rifampin: A broad-spectrum antibiotic used as part of combination therapy for tuberculosis, inhibiting bacterial RNA synthesis.

Ethambutol: An antitubercular agent that inhibits arabinosyl transferases involved in mycobacterial cell wall synthesis.